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These schemes of work were planned as part of the iGCSE course, but could be used for other courses. They include PowerPoints, activities, experiments, homework and formative assessment resources. The topics covered are: - Elements, compounds and mixtures - Atomic Structure - Isotopes - Ionic and Covalent Bonding - Conservation of Mass and Balancing Equations - Giant Ionic structures - Giant Covalent structures - Simple Covalent structures - Metallic structures - Testing for Ions

This unit was planned as part of the Chemistry IB Option B - Biochemistry scheme of work, and covers all the topics at SL. It would also be suitable for other schemes of work. It includes 6 full PowerPoints, along with student versions to use as notes, which have spaces for the students to add in missing information and activities for them to complete. It also includes exam questions for practice or assessment purposes Topics covered are: Introduction to Biochemistry - Metabolism - Biochemical reactions in terms of oxidation and reduction - Respiration - Photosynthesis - Hydrolysis and Condensation reactions Proteins - 2 amino acids and their behaviour as zwitterions - Gel electrophoresis - Paper chromatography - Peptides - Hydrolysis of peptides - Proteins - primary, secondary, tertiary and quaternary structures - Acid-base properties of amino acids and proteins - Acid-base buffers - Enzymes - Induced fit theory - Non competitive and competitive inhibition - The Michaelis-Menten equation - Protein Assays Lipids - Fatty acids - Triglycerides - Calculating the iodine number - Hydrolysis of triglycerides - Rancidity of fats - Energy values of fats - Phospholipids - Steroids (including cholesterol) - Sex hormones - Anabolic steroids Carbohydrates - Monosaccharides - Reducing sugars - Disaccharides - Polysaccharides - Starch, glycogen and cellulose Vitamins - Preventing deficiencies - Water and fat solubilities of vitamins - Vitamin A - Vitamin C - Vitamin D - Decomposition of vitamins Environmental Impacts of Biochemistry - Xenobiotics - Metabolism of xenobiotics - DDT - PCBs - Heavy metal toxicity - Pharmaceutically active compounds and detergents - Host-guest complexes - Polymers - Green Chemistry

This PowerPoint was planned as part of the IB scheme of work on Medicinal Chemistry, and covers the necessary content for the all of the Standard and Higher Level units. It would also be suitable for other post-16 courses. It includes 9 full PowerPoints, along with student versions to use as notes, which have spaces for the students to add in missing information and activities for them to complete. It also includes exam questions for practice or assessment purposes Topics covered are: Pharmaceutical Products and Drug Design - Routes of drug administration - Theraputic Effects of Drugs - The Placebo Effect - Side Effects - Calculation of the Therapeutic Index - The Therapeutic Window - Bioavailability - Tolerance and Addiction - Drug Action - Drug Development by both Drug Design and Drug Discovery Aspirin and Penicillin - History of Aspirin - Method of Producing Aspirin - Calculating the % Yield of Aspirin produced from Salicyclic Acid - Effects of Aspirin - Soluble Aspirin - Development of Penicillin - Structure of Penicllin - How Penicillin Works - Antibiotic Resistance Opiates - Morphine: Structure and action; side effects; withdrawal - How opiates cross the blood-brain barrier - Diamorphine pH regulation of the stomach - The need for stomach acid - pH calculations to determine the concentration of acid in the stomach - Antacids: equations for their reactions with stomach acid; side effects; calculation of quantity of acid neutralised - Regulation of acid production using both H2-histamine receptor blockers (Zantac) and proton pump inhibitors (Omeprazole and Esomeprazole) - Acid-base buffers: definition and calculations - Hydrogencarbonate and carbonate buffers Antivirals - The differences between viruses and bacteria - The structure of viruses - How viruses reproduce and replicate - How viruses are treated by interrupted stages of the replication process - Oseltamivir and Zanamivir - structure and action - HIV and AIDS - Treatment of HIV and AIDS Environmental impacts of Biochemistry - Effects of PACs on the environment - Antibiotic Resistance - Nuclear Waste (both LLW and HLW) - Chlorinated solvent waste - Supercritical fluid waste - Green Chemistry - Biotechnologies in Green Chemistry Taxol - The Discovery of Paclitaxel - Isolation of Taxol - Structure of Taxol - Semi-synthetic production of Taxol - Clinical use of Taxol - The use of chiral auxiliaries to produce one enantiomer of Taxol - Confirmation of the purity of a single enantiomer drug - Thalidomide Nuclear Medicine - The use of radionuclides in medicine - Types of ionising radiation - Radiotherapy - Radioactive Decay - Targeted alpha therapy - Boron neutron capture therapy - Use of gamma emitters in radiotherapy - Radiodiagnostics - Positron Emission Tomography - Use of Technetium-99m - Half life and decay constant calculations - Magnetic Resonance Imaging Drug Detection and Analysis - Worked example of the identification of aspirin by NMR, IR and Mass Spectrometry - Worked example of the identification of an unknown compound from NMR, IR and Mass Spectrometry - Extraction and purification of organic products - Worked example of hormone concentration using partition coefficients - How polarity affects the partition coefficients - Raoult´s Law - Fractional Distillation - Drug detection in sports - Drug detection in forensic science - Chemistry of breathalyzer tests - HPLC and Gas chromatography

Resources covering the iGCSE topics of Experimental Techniques Fundamental ideas Air and Water Metals and Metal Extraction Acids, Bases and Salts Organic Chemistry Moles